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Babu R. Dawadi Danda B. Rawat Shashidhar R. Joshi Pietro Manzoni Martina M. Keitsch 《International Journal of Network Management》2021,31(4):e2145
This paper studies a problem for seamless migration of legacy networks of Internet service providers to a software-defined networking (SDN)-based architecture along with the transition to the full adoption of the Internet protocol version 6 (IPv6) connectivity. Migration of currently running legacy IPv4 networks into such new approaches requires either upgrades or replacement of existing networking devices and technologies that are actively operating. The joint migration to SDN and IPv6 network is considered to be vital in terms of migration cost optimization, skilled human resource management, and other critical factors. In this work, we first present the approaches of SDN and IPv6 migration in service providers' networks. Then, we present the common concerns of IPv6 and SDN migration with joint transition strategies so that the cost associated with joint migration is minimized to lower than that of the individual migration. For the incremental adoption of software-defined IPv6 (SoDIP6) network with optimum migration cost, a greedy algorithm is proposed based on optimal path and the customer priority. Simulation and empirical analysis show that a unified transition planning to SoDIP6 network results in lower migration cost. 相似文献
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One of the main issues related to the reliable operation of network control systems concerns the design of mechanisms able to detect anomalies in the functioning of the communication network through which the control loops are closed. In this article, we address the problem of detecting the occurrence of packet losses and design a mechanism that can detect the occurrence of packet losses directly from process sensor data. Specifically, we propose a moving‐horizon estimation scheme that permits to detect if the packet‐loss rate exceeds prescribed thresholds, which are representative of stability and performance of the control system. We discuss theoretical properties of the proposed solution along with an approximation scheme with reduced computational burden. A numerical example is discussed to substantiate the analysis. 相似文献
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Roberta D’Ambrosio Alessio Aghemo Raffaele De Francesco Maria Grazia Rumi Enrico Galmozzi Stella De Nicola Cristina Cheroni Paul J. Clark Guido Ronchi Pietro Lampertico Massimo Colombo 《International journal of molecular sciences》2014,15(5):7213-7224
The interleukin 28B (IL28B) rs12979860 polymorphism is associated with treatment outcome in hepatitis C virus (HCV) genotype 1 and 4 patients. Its association with the histological features of chronic hepatitis C and disease severity needs further clarifications. To assess the correlation between IL28B genotype, HCV genotype and liver biopsy findings in untreated patients.
Materials and Methods
Pre-treatment liver biopsies from 335 HCV Caucasian patients (59% males, age 50 years) enrolled in the MIST study were staged for fibrosis and inflammation according to the METAVIR and the Ishak scoring systems; steatosis was dichotomized as <5% or ≥5%. IL28B was typed by Taqman Single Nucleotide Polymorphism (SNP) genotyping assay. HCV genotype was 1 in 151 (45%), 2 in 99 (30%), 3 in 50 (15%) and 4 in 35 (10%) patients. IL28B genotype was CC in 117 (34%), CT in 166 (49%) and TT in 52 (15%). At univariate analysis, the IL28B CC genotype was associated with severe portal inflammation in HCV-1 patients (CC vs. CT/TT: 86% vs. 63%, p = 0.005), severe lobular inflammation in HCV-2 patients (CC vs. CT/TT: 44% vs. 23%, p = 0.03), and less fatty infiltration in HCV-1 patients (CC vs. CT/TT: 72% vs. 51%, p = 0.02). Despite the lack of any association between IL28B and fibrosis stage, in HCV-3 patients IL28B CC correlated with METAVIR F3–F4 (CC vs. CT/TT: 74% vs. 26%, p = 0.05). At multivariate analysis, the genotype CC remained associated with severe portal inflammation in HCV-1, only (Odds Ratio (OR): 95% Confidence Interval (CI): 3.24 (1.23–8.51)). IL28B genotype is associated with the histological features of chronic hepatitis C in a HCV genotype dependent manner, with CC genotype being independently associated with severe portal inflammation. 相似文献17.
Pietro Canepa Nazzareno Marignetti Umberto Rognoni Seba Calgari 《Water research》1988,22(12):1491-1494
The purpose of this work was to verify the combined application of membranes and adsorption processes to the treatment of vegetation waters coming from olive oil factories. The described pilot plant worked for about 6 months using polysulfone ultrafiltration membranes, absorbing polymers and polypiperazine amide reverse osmosis membranes. The process was optimized so that from wastewater entering with a COD content of about 90,000 ppm it was possible to obtain a COD reduction of about 99% with the recovery of polyphenols to use in alimentary industries and of a “concentrated paste” for oil extraction, phurphurale production or combustion. Also evaluated was the economical feasibility of industrial application calculating that the total cost of the treatment was close to 3 c per liter. 相似文献
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Bergonzi R De Palma G Specchia C Dinolfo M Tomasi C Frusca T Apostoli P 《The Science of the total environment》2011,409(15):2888-2893
Some organochlorine compounds, such as polychlorinated biphenyls (PCBs), have a tendency to bioaccumulate in humans and predators at the top of the food chain. We have recently confirmed the transplacental transfer of these compounds and the present study has been designed on the same material with the aim of investigating their potential health effects on newborns from 70 pregnant women, resident in a Northern Italy industrial town. Organochlorine compounds [namely, p,p′-dichlorodiphenyltrichloroethane (p,p′-DDT), p,p′-dichlorodiphenyldichloroethene (p,p′-DDE), hexachlorobenzene (HCB), and PCBs] have been analyzed both in cord and maternal serum, placenta, and maternal subcutaneous adipose tissue by GC-MSD. p,p′-DDT levels in the adipose tissue resulted significantly (p < 0.05) related to birth length. Mothers of neonates born by preterm programmed caesarean delivery showed significantly (p < 0.005 for both) higher serum p,p′-DDE serum concentrations and p,p′-DDT levels in the adipose tissue, as compared to mothers delivering at term. 相似文献
19.
High‐tuning‐range CMOS band‐pass IF filter based on a low‐Q cascaded biquad optimization technique 下载免费PDF全文
Pietro Monsurrò Salvatore Pennisi Giuseppe Scotti Alessandro Trifiletti 《International Journal of Circuit Theory and Applications》2015,43(11):1615-1636
A design procedure for high‐order continuous‐time intermediate‐frequency band‐pass filters based on the cascade of low‐Q biquadratic cells is presented. The approach is well suited for integrated‐circuit fabrication, as it takes into account the maximum capacitance spread dictated by the available technology and maximum acceptable sensitivity to component variations. A trade‐off between noise and maximum linear range is also met. A novel, wide‐tuning‐range transconductor topology is also described. Based on these results, a 10‐pole band‐pass filter for a code division multiple‐access satellite receiver has been designed and tested. The filter provides tunable center frequency (f0) from 10 to 70 MHz and exhibits a 28‐MHz bandwidth around f0 = 70 MHz with more than 39‐dB attenuation at f0/2 and 2f0. Third‐order harmonic rejection is higher than 60 dB for a 1‐Vpp 70‐MHz input, and equivalent output noise is lower than 1 mVrms. The circuit is fabricated in a 0.25‐µm complementary metal oxide semiconductor process, and the core consumes 12 mA from a 2.5‐V supply, offering the best current/pole ratio figure. The die area resulted to be 0.9 × 1.1 mm2. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
20.
Potent,Metabolically Stable 2‐Alkyl‐8‐(2H‐1,2,3‐triazol‐2‐yl)‐9H‐adenines as Adenosine A2A Receptor Ligands 下载免费PDF全文
Dr. Silvia Pace Dr. Giandomenico Brogin Dr. Maria Antonietta Stasi Dr. Teresa Riccioni Franco Borsini Dr. Francesca Capocasa Dr. Francesco Manera Carlo Tallarico Dr. Pietro Grossi Dr. Federica Vacondio Dr. Michele Bassi Dr. Francesca Bartoccini Dr. Simone Lucarini Dr. Giovanni Piersanti Prof. Giorgio Tarzia Walter Cabri Dr. Patrizia Minetti 《ChemMedChem》2015,10(7):1149-1152
Inhibition of adenosine A2A receptors has been shown to elicit a therapeutic response in preclinical animal models of Parkinson’s disease (PD). We previously identified the triazolo‐9H‐purine, ST1535, as a potent A2AR antagonist. Studies revealed that ST1535 is extensively hydroxylated at the ω‐1 position of the butyl side chain. Here, we describe the synthesis and evaluation of derivatives in which the ω‐1 position has been substituted (F, Me, OH) in order to block metabolism. The stability of the compounds was evaluated in human liver microsomes (HLM), and the affinity for A2AR was determined. Two compounds, (2‐(3,3‐dimethylbutyl)‐9‐methyl‐8‐(2H‐1,2,3‐triazol‐2‐yl)‐9H‐purin‐6‐amine ( 3 b ) and 4‐(6‐amino‐9‐methyl‐8‐(2H‐1,2,3‐triazol‐2‐yl)‐9H‐purin‐2‐yl)‐2‐methylbutan‐2‐ol ( 3 c ), exhibited good affinity against A2AR (Ki=0.4 nM and 2 nM , respectively) and high in vitro metabolic stability (89.5 % and 95.3 % recovery, respectively, after incubation with HLM for two hours). 相似文献